Young versus old age at diagnosis confers distinct genomic profiles in patients with polycythemia vera
Jared S. Fowles,1 Joan How,1 Maggie J. Allen,1 Stephen T. Oh1 Leukemia (2019) 33:1522–1526
Pediatric and adult dilated cardiomyopathy represent distinct pathological entities
Maghna D. Patel,1 Jayaram Mohan,2 Caralin Schneider,2 Geetika Bajpai,2 Enkhsaikhan Purevjav,3 Charles E. Canter,1 Jeffrey Towbin,3 Andrea Bredemeyer,2 and Kory J. Lavine 2,4,5 JCI Insight. 2018; 2(14):e94382. (Epub 2017 July 20.)
Prophylactic probiotics for cancer therapy-induced diarrhoea: a meta-analysis
Wardill HR, Van Sebille YZA, Ciorba MA, Bowen JM. Curr Opin Support Palliat Care. 2018 Mar 14.
Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling
Dmitri Samovski, Pallavi Dhule, Terri Pietka, Miriam Jacome-Sosa, Eric Penrose, Ni-Huiping Son, Robert C. Flynn, Kooresh I. Shoghi, Krzysztof L. Hyrc, Ira J. Goldberg, Eric R. Gamazon and Nada A. Abumrad Diabetes 2018 May; db171226. https://doi.org/10.2337/db17-1226
Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling.
Samovski D,1 Dhule P,2 Pietka T,2 Jacome-Sosa M,2 Penrose E,2 Son NH,3 Flynn CR4 Shoghi KI5Hyrc KL6 Goldberg IJ3Gamazon ER, 7,8, and Abumrad NA, 1. Diabetes. 2018 Jul;67(7):1272-1284. doi: 10.2337/db17-1226. Epub 2018 May 10.
Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being. Gerontology
Bertozzi B, Tosti V, Fontana L. Gerontology. 2017; 63(1): 13-9. (Epub 2016 May 14.)
Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism are Associated with Protein Ingestion-Induced Insulin Resistance
Harris LLS, Smith GI, Patterson BW, Ramaswamy RS, Okunade A, Kelly SC, Porter LC, Klein S, Yoshino J, Mittendorfer B: Diabetes 2017 (PMID: 28473464)
Dietary protein, aging and nutritional geometry
Simpson SJ, Le Couteur DG, Raubenheimer D, Solon Biet SM, Cooney GJ, Cogger VC, Fontana L. Aging Research Reviews. 2017 Oct; 39:78-86.
Calorie Restriction in Humans: An Update
Most J, Tosti V, Redman LM, Fonana L. Aging Research Reviews 2017 Oct; 39: 36-45. (Epub 2016 Aug 17.)
Renal and Systemic Effects of Calorie Restriction in Type 2 Diabetes With Abdominal Obesity: A Randomized Controlled Trial
Ruggenenti P, Abbate M, Ruggiero B, Rota S, Trillini M, Aparicio C, Parvanova A, Iliev IP, Pisanu G, Perna A, Russo A, Diadei O, Martinetti D, Cannata A, Carrara F, Ferrari S, Stucchi N, Remuzzi G, Fontana L. Diabetes. 2017 Jan; 66(1): 75-86. (Epub 2016 Sep 15.).
Gnotobiotic Mouse Models for Identifying Consistent Effects of Different Nutritional Lifestyles on the Gut Microbiota of Multiple Unrelated Humans
Griffin NW, Ahern PP, Cheng J, Heath AC, Fontana L, Gordon JI. Cell Host and Microbe. 2017: 21(1): 84-96.
A Simple Culture System for Long-Term Imaging of Individual C. Elegans
Pittman WE, Sinha DB, Zhang WB, Kinser HE & Pincus Z. Lab Chip. 2017; 77, 71 (2017). (open access available 2018-11-07.)
Successful Completion of the Pilot Phase of a Randomized Controlled Trial Comparing Sentinel Lymph Node Biopsy to No Further Axillary Staging in Patients with Clinical T1-T2 N0 Breast Cancer and Normal Axillary Ultrasound
Cyr AE, Tucker N, Ademuyiwa F et al. J Am Coll Surg.2016 Aug;223(2):399-407.
Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36
Love-Gregory L, Kraia AT, Allum F et al. J Lipid Res. 2016 Dec57(12):2176-84.
Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health
Zhang WB, Sinha DB, Pittman WE, Hvatum E, Stroustrup N, Pincus Z. Cell Systems, 2016 Oct 26;3(4):333-45.
NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice
Stromsdorfer KL, Yamaguchi S, Yoon MJ, Moseley AC, Franczyk MP, Kelly SC, Qi N, Imai S, Yoshino J. Cell Reports. 2016 Aug 16;16(7):1851-60.
Cerebrospinal Fluid Biomarkers and Reserve Variables as Predictors of Future "Non-Cognitive" Outcomes of Alzheimer's Disease
Ingber AP, Hassenstab J, Fagan AM, Benzinger TL, Grant EA, Holtzman DM, Morris JC, Roe CM. J Alzheimers Dis. 2016;52(3):1055-64.
Human Metabolome-Derived Cofactors are Required for the Antibacterial Activity of Siderocalin in Urine
Shields-Cutler RR, Crowley JR, Miller CD, Stapleton AE, Cui W, Henderson JP. The Journal of Biological Chemistry. 2016 Oct. 25.
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle
Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L. Cell Reports. 2016 Jan 26;14(3):422-8.
Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health
Fontana L, Cummings NE, Arriola Apelo SI et al. Cell Reports, 2016 Jul 12;16(2):520-30.
Calorie restriction in humans: An update
Most J, Tosti V, Redman LM, Fontana L. Ageing Res Rev., 2016 Aug 17.
High-protein intake during weight-loss therapy eliminates the weight loss-induced improvement in insulin action in obese postmenopausal women
Smith GI, Yoshino J, Kelly SC, Reeds DN, Okunade A, Patterson BW, Klein S, Mittendorfer B. Cell Reports. Oct. 11, 2016.
Predicting all-cause mortality from basic physiology in the Framingham Heart Study
Zhang WB, Pincus Z. Aging Cell, 2016 Feb 15. (1):39-48.
Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity
Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC, de Las Fuentes L, He S, Okunade AL, Patterson BW, Klein S. Cell Metabolism, 2016 Feb 22. pii: S1550-4131(16)30053-5. doi: 10.1016/j.cmet.2016.02.005. [Epub ahead of print]
Probiotic Gut Bacteria Enhance Cancer Immunotherapy in a Mouse Model of Melanoma
Dey N, Ciorba MA. Gastroenterology. 2016 May 26. pii: S0016-5085(16)34458-4. doi: 10.1053/j.gastro.2016.05.015. [Epub ahead of print] No abstract available.
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
Kathryn F. Mills, Shohei Yoshida, Liana R. Stein, ..., Koji Uchida, Jun Yoshino, Shin-ichiro Imai Cell Metabolism, December 13, 2016 , 24, 1–12 [Epub ahead of print]
Combined associations of body weight and lifestyle factors with all-cause and cause-sepcific mortality in men and women: prospective cohort study
Veronese N, Li Y, Manson JE, Willett WC, Fonana L, Hu FB. BMJ 2016 Nov. 24; 355.
Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss
Su X, Magkos F, Zhou D, Eagon JC, Fabbrini E, Okunade AL, Klein S. Obesity, 2015 Feb; 23(2):329-34
Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer
Morrissey JJ, Mobley J, Figenshau RS, Vetter J, Bhayani S, Kharasch ED Mayo Clinic Proceedings, 2015 Jan; 90(1):35-42
Evaluation of urine aquaporin-1 and perilipin-2 concentrations as biomarkers to screen for renal cell carcinoma: A prospective cohort study
Morrissey JJ, Mellnick VM, Luo J, Siegel MJ, Figenshau RS, Bhayani S, Kharasch ED JAMA Oncology, 2015 May; 1(2):204-12
Human urinary composition controls antibacterial activity of siderocalin
Shields-Cutler RR, Crowley JR, Hung CS, Stapleton AE, Aldrich CC, Marschall J, Henderson JP The Journal of Biological Chemistry, 2015 April 10,
Promoting health and longevity through diet: from model organisms to humans
Fontana L, Partridge L Cell, 2015 March 25; 161(1); 106-18
Calorie restriction, endothelial function and b¬lood pressure homeostasis
Spelta F, Bertozzi B, Cominacini L, Fontana L Vascul Pharmacol, 2015 Feb-Mar, 65-6:1-2.
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population
Levine M, Suarez J, Brandhorst S, Balasubramanian, Cheng CW, Madia F, Fontana L, Mirisola MP, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins E, Longo VD Cell Metabolism 2014 Mar 4;19(3):407–17
Probiotics to prevent gastrointestinal toxicity from cancer therapy: an interpretive review and call to action
Ciorba MA, Hallemeier CL, Stenson WF, Parikh PJ. Curr Opin Support Palliat Care. 2015 Jun;9(2):157-62. doi: 10.1097/SPC.0000000000000134. Review. PMID: 25872116
Network Analysis Reveals Sex- and Antibiotic Resistance-Associated Antivirulence Targets in Clinical Uropathogens
Parker KS, Wilson JD, Marschall J, Mucha PJ, Henderson JP. ACS Infect Dis. 2015 Nov 13;1(11):523-32.
“Noncognitive” symptoms of early Alzheimer disease: a longitudinal analysis
Masters MC, Morris JC, Roe CM. Neurology. 2015 Feb. 10; 84(6): 617-22.
Energy requirements in nonobese men and women: results from CALERIE
Redman LM, Kraus WE, Bhapkar M, Das SK, Racette SB, Martin CK, Fontana L, Wong WW, Robert SB, Ravussin E, for the CALERIE Study Group Am J Clin Nutr Jan 2014
Levine ME, Suarez JA, Brandhorst S, Balasubramanian P; Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo, VD Cell Metabolism 19, 407-17, March 4, 2014
Optimal body weight for health and longevity: bridging basic, clinical, and population research
Fontana L, Hu FB Aging Cell (2014) pp 1-10
Postprandial plasma incretin hormones in exercise-trained versus untrained subjects
Weiss EP, Royer NK, Fisher JS, Holloszy JO, Fontana L Med Sci Sports Exerc 2014 Jun; 46(6): 1098-103
Cytochrome P450 gene variants, race and mortality among clopidogrel-treated patients after acute myocardial infarction
Cresci S, Depta JP, Lenzini PA, Li AY, Lanfear DE, Province MA, Spertus JA,. Bach RG Circ Cardiovasc Genet 2014 Jun;7(3):277-86
Urinary concentrations of aquaporin-1 and perilipin-2 in patients with renal cell carcinoma correlate with tumor size and stage but not grade
Morrissey JJ, Mobley J, Song J, Vetter J, Luo J, Bhayani S, Figenshau RS , Kharasch ED Urology 2014 Jan;83(1): 256
Activation of miR-9 by human papillomavirus in cervical cancer
Liu W, Gao g,, Hu X, Wang Y, Schwarz JK, Chen JJ, Grigsby PW, Wang X Oncotarget, 2014 Nov 30; 5(22):11620-30
CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction
Chen LS, Bach RG, Lenzini PA, Spertus JA, Bierut LJ, Cresci S Nicotine Tob Res 2014 Sep;16(9):1224-31
What are the roles of calorie restriction and diet quality in promoting healthy longevity?
Rizza W, Veronese N, Fontana L Ageing Research Reviews 2014 Jan; 13:38-45
Medical research: treat ageing
Fontana L, Kennedy BK, Longo VD, Seals D, Melov S Nature 2014 Jul 24;511(7510):405-7
Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later
Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D; Sutphen CL, Benzinger TL, Mintun MA, Holtzman DM, Morris JC Neurology 2013 May 7;80(19):1784-91
The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma
Morrissey JJ, Kharasch ED The Journal of Urology, 2013 May; 189(5):1913-20
Assessing the diagnostic accuracy (DA) of the Spanish version of the informant-based AD8 questionnaire
Carnero Pardo C, de la Vega Cotarelo R, López Alcalde S, Martos Aparicio C, Vilchez Carrillo R, Mora Gavilán E, Galvin JE Neurologia 2013 Mar;28(2):88-94
“Deficiency” of mitochondria in muscle does not cause insulin resistance
Holloszy JO Diabetes 2013 Apr;62 (4): 1036-1040
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L Aging Cell 2013 Aug;12(4):645-51
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model
Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD Aging Cell 2013 Apr;12(2):257-6
Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients
Fontana L, Addante F, Copetti M, Paroni G, Fontana A, Sancarlo D, Pellegrini F, Ferrucci L, Pilotto A Aging Cell 2013 Jun;12(3):459-66
Will calorie restriction work in humans?
Cava E, Fontana L Aging 2013 Jul;5(7):507-14
Serum from humans on long-term calorie restriction enhances stress resistance in cell culture
Omodei D, Licastro D, Salvatore F, Crosby SD, Fontana L Aging 2013 Aug;5(8):599-606
Energy efficiency as a unifying principle for human, environmental, and global health
Fontana L, Atella V, Kammen DM F1000Research 2013, 2:101
Multiple dietary supplements do not affect metabolic and cardiovascular health
Soare A, Weiss EP, Holloszy JO, Fontana L Aging 2013 Sep 4 (Epub)
Dietary protein restriction inhibits tumor growth in human xenograft models
Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo VD, Nguyen H, Vessella R, Pili R Oncotarget 2013 Dec;4(12):2451-61
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
Fabbrini E, Cella M, McCartney SA, Fuchs A, Abumrad NA, Pietka TA, Chen Z, Finck BN, Han DH, Magkos F, Conte C, Bradley D, Fraterrigo G, Eagon JC, Patterson BW, Colonna M, Klein S Gastroenterology 2013 Aug;145(2):366-74
CSF biomarkers of Alzheimer disease: “noncognitive” outcomes
Roe CM, Fagan AM, Grant EA, Holtzman DM, Morris JC Neurology 2013 Dec 3;81(23):2028-31
Accurate measurement of nicotinamide adenine dinucleotide (NAD+) with high-performance liquid chromatography
Yoshino J, Imai S Methods Mol Biol 2013;1077:203-15
An exploration of salivation patterns in normal weight and obese children
Aspen VA, Stein RI, Wilfley DE Appetite 2012 Apr 58(2):539-42
Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults
Villareal DT, Smith GI, Shah K, Mittendorfer B Obesity 2012 Sep;20 (9):1780-6
Adrenergic-pathway gene variants influence beta-blocker-related outcomes after acute coronary syndrome in a race-specific manner
Cresci S, Dorn GW 2nd, Jones PG, Beitelshees, AL, Li AY, Lenzini PA, Province MA, Spertus JA, Lanfear DE Journal of the American College of Cardiology 2012 Sep 4;60(10):898-907
Growth factors, nutrient signaling, and cardiovascular aging
Fontana L, Vinciguerra M, Longo VD Circulation Research 2012 Apr 13;110(8):1139-50
Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss as compared to calorie restriction
Murphy JC, McDaniel JL, Mora K, Villareal DT, Fontana L, Weiss EP Journal of Applied Physiology 2012 Jan;112(1):79-85
Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis
Paroni G, Seripa D, Panza F, Addante F, Copetti M, D'Onofrio G, Pellegrini F, Fontana L, Pilotto A Age (Dordr) 2012 Aug;34(4):949-68
Sexually dimorphic effect of aging on skeletal muscle protein synthesis
Smith GI, Reeds DN, Hall AM, Chambers KT, Finck BN, Mittendorfer B Biology of Sex Differences 2012 May 23;3(1):11
Caloric restriction may reverse age-related autonomic decline in humans
Stein PK, Soare A, Meyer TE, Cangemi R, Holloszy JO, Fontana L Aging Cell 2012 Aug;11(4):644-50
Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness
Weiss EP, Villareal DT, Ehsani AA, Fontana L, Holloszy JO Aging Cell 2012 Oct;11(5):876-84
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, Gu CC, Kunz I, Rossi Fanelli F, Patterson BW, Klein S Cell Metabolism 2012 Nov 7;16(5):658-64
[The reliability and validity of Chinese version of AD8]. (article in Chinese)
Li T, Wang HL, Yang YH, Galvin JE, Morris JC, Yu X Zhonghua Nei Ke Za Zhi 2012 Oct;51(10):777-80
Predicting road test performance in adults with cognitive or visual impairment referred to a Veterans Affairs Medical Center driving clinic
Niewoehner PM, Henderson RR, Dalchow J, Beardsley TL, Stern RA, Carr DB Journal of the American Geriatric Society 2012 Nov;60(11):2070-4
Ginseng and ginsenoside re do not improve ß-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes
Reeds DN, Holloszy JO, Patterson BW, Polonsky KS, Okunade A, Klein S Diabetes Care Volume 34, May 2011 1071-6
Intermittent supplementation with rapamycin as a dietary restriction mimetic
Longo VD, Fontana L Aging (Albany NY) 2011 Nov;3(11):1039-40
Application of AD8 questionnaire to screen very mild dementia in Taiwanese
Yang YH, Galvin JE, Morris JC, Lai CL, Chou MC, Liu CK American Journal of Alzheimer’s Disease & Other Dementias 2011 Mar;26(2):134-8
Caloric restriction: powerful protection for the aging heart and vasculature
Weiss EP, Fontana L American Journal of Physiology – Heart and Circulatory Physiology 2011 Oct;301(4):H1205-19
Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, obese, older adults
Villareal DT, Smith GI, Sinacore DR, Shah K, Mittendorfer B Obesity 2011 Feb;19(2):312-8
Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial
Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B American Journal of Clinical Nutrition 2011 Feb;93(2):402-12
Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women
Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B Clinical Science (London, England) 2011 Sep;121(6):267-78
Calorie restriction and prevention of age-associated chronic disease
Omodei D, Fontana L FEBS Letters 2011 Jun 6;585(11):1537-42
Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition
Villareal DT, Kotyk J,J Armamento-Villareal RC, Kenguva V, Seaman P, Shahar A, Wald MJ, Kleerekoper M, Fontana L Aging Cell 2011 Feb; 10(1):96-102
Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans
Soare A, Cangemi R, Omodei D, Holloszy JO, Fontana L Aging 2011 Apr;3(4):374-9
Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial
Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye RL, Bach RG; BARI 2D Study Group Circulation 2011 Sep 27;124(13):1426-34
Dementia screening, biomarkers and protein misfolding: Implications for public health and diagnosis
Galvin JE Prion 2011 Jan-Mar;5(1):16-21
AD8-Brazil: cross-cultural validation of the ascertaining dementia interview in Portuguese
Correia CC, Lima F, Junqueira F, Campos MS, Bastos O, Petribú K, Laks J, Galvin JE Journal of Alzheimer’s Disease.2011;27(1):177-85
Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosysthesis
Imai S FEBS Lett 2011 Jun 6;585(11): 1657-62
Predicting road test performance in drivers with dementia
Carr DB, Barco PP, Wallendorf MJ, Snellgrove CA, Ott BR Journal of the American Geriatric Society 2011 Nov;59(11):2112-7
Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
Yoshino J, Mills KF, Yoon JY and Imai S. Cell Metab. 2011 Oct 5;14(4):528-36.
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
Imai S, Guarente L Trends Pharmacol Sci 2010 May;31(5):212-20
Relationship of dementia screening tests with biomarkers of Alzheimer's disease
Galvin JE, Fagan AM, Holtzman DM, Mintun MA, Morris JC Brain. 2010 Nov;133(11):3290-300
A microRNA expression signature for cervical cancer prognosis
Hu X, Schwarz JK, Lewis JS Jr, Huettner PC, Rader JS, Deasy JO, Grigsby PW, Wang X Cancer Research 2010 Feb 15;70(4):1441-8
Extending healthy life span – from yeast to humans
Fontana L, Partridge L, Longo VD Science 2010 Apr 16;328(5976):321-6
Long-term effects of calorie restriction on serum sex-hormones concentrations in men
Cangemi R, Friedmann, AJ, Holloszy JO, Fontana L Aging Cell 2010 Apr;9(2):236-42
Calorie restriction and cancer prevention: metabolic and molecular mechanisms
Longo VD, Fontana L Trends in Pharmacological Sciences 2010 Feb;31(2):89-98
Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production
Fontana L, Klein S, Holloszy JO Age 2010 Mar;32(1):97–108
TRB3 function in cardiac endoplasmic reticulum stress
Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ Circulation Research 2010 May 14;106(9):1516-23
A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis
Imai, S Pharmacological Research 2010 Jul;62(1):42-7
Organizational support and volunteering benefits for older adults
Tang F, Choi E, Morrow-Howell N The Gerontologist 2010 Oct;50(5):603-12
Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction
Fontana L Experimental Gerontology 2009 Jan-Feb;44(1-2):41-5
“Clocks” in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging
Imai, S Biochimica et Biophysica Acta 2010 Aug;1804(8):1584-90
Driving retirement in older adults with dementia
Croston J, Meuser TM, Berg-Weger M, Grant EA, Carr DB Topics in Geriatric Rehabilitation 2009 Apr 1;25(2): 154-62
The scientific basis of caloric restriction leading to longer life
Fontana L Current Opinion in Gastroenterology 2009 Mar;25(2):144-50
Modulating human aging and age-associated diseases
Fontana L Biochimca et Biophysica Acta 2009 Oct;1790 (10):1133-8
SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty
Imai S Current Opinion in Clinical Nutrition and Metabolic Care 2009 Jul;12(4):350-6
Who benefits from volunteering: Variations in perceived benefits
Morrow-Howell N, Hong SI, Tang F The Gerontologist 2009 Feb;49 (1):91-102
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C,Takahashi JS, Imai S, Bass J Science 2009 May 1;324(5927): 651-4
MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets
Muslin AJ Clinical Science (London, England) 2008 Oct;115(7):203-18
The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan
Collins JJ, Evason K, Pickett CL, Schneider DL, Kornfeld K PLoS Genetics 2008 Oct;4(10): e1000230
The measurement and analysis of age-related changes in Caenorhabditis elegans
Collins JJ, Huang C, Hughes S, Kornfeld K WormBook 2008 Jan 24:1-21
Reduction of overweight and eating disorder symptoms via the Internet in adolescents: A randomized controlled trial
Doyle AC, Goldschmidt A, Huang C, Winzelberg AJ, Taylor CB, Wilfley DE Journal of Adolescent Health 2008 Aug;43 (2): 172-9
Valproic acid extends Caenorhabditis elegans lifespan
Evason K, Collins JJ, Huang C, Hughes S, Kornfeld K Aging Cell 2008 Jun;7(3):305-17
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans
Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO Aging Cell 2008 Oct;7(5):681-7
Translational approaches to addressing complex genetic pathways in colorectal cancer
Early DS, Fontana L, Davidson NO Translational Research 2008 Jan;151(1):10-6
Calorie restriction and cardiometabolic health
Fontana L European Journal of Cardiovascular Prevention and Rehabilitation 2008 Feb;15(1):3-9
Changes in weight and health behaviors from freshman through senior year of college
Racette, SB, Deusinger SS, Strube MJ, Highstein GR, Deusinger RH J Nutr Educ Behav 2008 Jan-Feb;40(1):39-42
Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk
Fontana L, Meyer TE, Klein S. Holloszy JO Rejuvenation Res 2007 Jun;10(2):225-34
Aging, adiposity and calorie restriction
Fontana L, Klein S JAMA 2007 Mar 7;297(9):986-94
Evaluation of cognitive impairment in older adults: combining brief informant and performance measures
Galvin JE, Roe CM, Morris JC Archives of Neurology 2007 May,64(5):718-24
Patient’s rating of cognitive ability: using the AD8, a brief informant interview, as a self-rating tool to detect dementia
Galvin JE, Roe CM, Coats MA, Morris JC Archives of Neurology 2007 May;64(5):725-30
Quantifying the usefulness of CT in evaluating seniors with abdominal pain
Lewis LM, Klippel AP, Bavolek RA, Ross LM, Scherer TM, Banet GA European Journal of Radiology 2007 Feb;61(2):290-6
Productive engagement and late life physical and mental health: Findings from a nationally representative panel study
Hinterlong JE, Morrow-Howell N, Rozario PA Research on Aging 2007 Jul;29(4):348-70
Effects of anticonvulsant drugs on life span
Kornfeld K, Evason K Archives of Neurology 2006 Apr;63(4):491-6
Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans
Collins JJ, Evason K, Kornfeld K Experimental Gerontology 2006 Oct;41(10):1032-9
Validity and reliability of the AD8 informant interview in dementia
Galvin JE, Roe CM, Xiong C, Morris JC Neurology 2006 Dec 12;67(11):1942-8
Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults
Villareal DT, Miller BV III, Banks M, Fontana L, Sinacore DR, Klein S The American Journal of Clinical Nutrition 2006 Dec;84(6):1317–23
Anticonvulsant medications extend worm life-span
Evason K, Huang C, Yamben I, Covey DF, Kornfeld K Science 2005 Jan 14;307(5707):258-62
The AD8: a brief informant interview to detect dementia
Galvin JE, Roe CM, Powlishta KK, Coats MA, Muich SJ, Grant E, Miller JP, Storandt M, Morris JC Neurology 2005 Aug 23;65(4):559-64
Obesity in older adults: Technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society
Villareal DT, Apovian CM, Kushner RF, Klein S Obesity Research 2005 Nov;13(11):1849-63
Effects of volunteering on the well-being of older adults
Morrow-Howell N, Hinterlong J, Rozario PA, Tang F The Journal of Gerontology Series B, Psychological Sciences and Social Sciences. 2003 May;58(3):S137-45
Predictors of mortality in younger and older patients with heart failure and preserved or reduced left ventricular ejection fraction
Kerzner R, Gage BF, Freedland KE, Rich MW American Heart Journal 2003 Aug;146(2):286-90
Identifying factors associated with disability-related differences in breast cancer screening (United States)
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