Publications

Investigations funded by the Longer Life Foundation have resulted to date in 151 articles in peer-reviewed medical journals. Find them here.

View Peer-Reviewed Articles

2019 Publications

Young versus old age at diagnosis confers distinct genomic profiles
in patients with polycythemia vera

Fowles JS,¹ How J,¹ Allen MJ,¹ Oh ST.¹
Leukemia (2019) 33:1522–1526

Pubmed Abstract
Comparative Genomics of Antibiotic-Resistant Uropathogens
Implicates Three Routes for Recurrence of Urinary Tract
Infections

Thänert R,^a,b Reske KA,^c Hink T,^cWallace TA,^c Wang B,^a,b Schwartz DJ, a,d Seiler S,^cCass C,^c Burnham CD,^b,d,eDubberke ER,^c Kwon JH,^cDantas G,^a,b,e,f for the CDC Prevention Epicenter Program
Clinical Science and Epidemiology (2019) e01977-19

Pubmed Abstract

2018 Publications

Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms

Tosti V, Bertozzi B, Fontana L.
Journal of Gerontology: Biological Sciences. 2018 Mar 2; 73(3):318-26.

Pubmed Abstract
The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M.
Aging Cell 2018 Jun; 17(3): e12746.

Pubmed Abstract
Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

Cignarella F, Cantoni C, Ghezzi L, Salter A, Dorsett Y, Chen L, Phillips D, Weinstock GM, Fontana L, Cross AH, Zhou Y, Piccio L.
Cell Metabolism. 2018 Jun 5; 27(6): 1222-35.

Pubmed Abstract
Interventions to promote cardiometabolic health and slow cardiovascular ageing

Fontana L. Nature Reviews Cardiology. 2018 Sep; 15(9): 566-77.

Pubmed Abstract
Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution

Contreras NA, Fontana L, Tosti V, Nikolich-Žugich J.
Geroscience. 2018 Jun; 40(3): 279-91.

Pubmed Abstract
Low-protein diet in cancer: ready for prime time?

Pili R, Fontana L. Nature Reviews Endocrinology. 2018 May 15; 14(7): 384-6.

Abstract
Caloric Restriction and Cellular Senescence: Mechanisms of Ageing and Development

Fontana L, Nehme J, Demaria M.
Mechanisms of Ageing and Development. 2018 Dec; 176: 19-23.

Pubmed Abstract
Sarcosine is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

Walters RO, Arias E, Diaz A, Burgos ES, Guan F, Tiano S, Mao K, Green CL, Qiu Y, Shah H, Wang D, Hudgins AD, Tabrizian T, Tosti V, Shechter D, Fontana L, Kurland IJ, Barzilai N, Cuervo AM, Promislow DEL, Huffman DM.
Cell Reports. 2018 Oct 16; 25(3): 663-76.

Pubmed Abstract
Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms

Treviño-Villarreal JH, Reynolds JS, Bartelt A, Langston PK, MacArthur MR, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace LE, Mejia P, Trocha K, Kajitani GS, Longchamp A, Harputlugil E, Gathungu R, Bird SS, Bullock AD, Figenshau RS, Andriole GL, Thompson A, Heeren J, Ozaki CK, Kristal BS, Fontana L, Mitchell JR.
JCI Insight. 2018 Nov 2; 3(21).

Pubmed Abstract
Prophylactic probiotics for cancer therapy-induced diarrhoea: a meta-analysis

Wardill HR, Van Sebille YZA, Ciorba MA, Bowen JM.
Curr Opin Support Palliat Care. 2018 Mar 14.

Pubmed Abstract
Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling

Dmitri Samovski, Pallavi Dhule, Terri Pietka, Miriam Jacome-Sosa, Eric Penrose, Ni-Huiping Son, Robert C. Flynn, Kooresh I. Shoghi, Krzysztof L. Hyrc, Ira J. Goldberg, Eric R. Gamazon and Nada A. Abumrad
Diabetes 2018 May; db171226. https://doi.org/10.2337/db17-1226

Abstract
Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling

Dmitri Samovski, Pallavi Dhule, Terri Pietka, Miriam Jacome-Sosa, Eric Penrose, Ni-Huiping Son, Robert C. Flynn, Kooresh I. Shoghi, Krzysztof L. Hyrc, Ira J. Goldberg, Eric R. Gamazon and Nada A. Abumrad
Diabetes 2018 May; db171226. https://doi.org/10.2337/db17-1226

Abstract
Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling

Samovski D,¹ Dhule P,² Pietka T,² Jacome-Sosa M,² Penrose E,² Son NH,³ Flynn CR⁴ Shoghi KI⁵Hyrc KL⁶ Goldberg IJ³Gamazon ER, ^7,8, and Abumrad NA, ¹.
Diabetes. 2018 Jul;67(7):1272-1284. doi: 10.2337/db17-1226. Epub 2018 May 10.

Pubmed Abstract
Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy

Orillion A, Damayanti NP, Shen L, Adelaiye-Ogala R, Affronti H, Elbanna M, Chintala S, Ciesielski M, Fontana L, Kao C, Elzey BD, Ratliff TL, Nelson DE, Smiraglia D, Abrams SI, Pili R.
Clinical Cancer Research. 2018 Dec 15; 24(24): 6383-95.

Pubmed Abstract
Trends in Age-Related Disease Burden and Healthcare Utilization

Atella V, Piano-Mortari A, Kopinska J, Belotti F, Lapi F, Cricelli C, Fontana L.
Aging Cell 2018; 18(1): e12861.

Abstract

2017 Publications

The science of nutritional modulation of aging

Fontana L.
Ageing Research Reviews. 2017 Oct; 39: 1-2.

Pubmed Abstract
Perspective: Improving Nutritional Guidelines for Sustainable Health Policies: Current Status and Perspectives

Magni P, Bier DM, Pecorelli S, Agostoni C, Astrup A, Brighenti F, Cook R, Folco E, Fontana L, Gibson RA, Guerra R, Guyatt GH, Ioannidis JP, Jackson AS, Klurfeld DM, Makrides M, Mathioudakis B, Monaco A, Patel CJ, Racagni G, Schünemann HJ, Shamir R, Zmora N, Peracino A.
Advances in Nutrition. 2017 Jul 14; 8(4): 532-45.

Pubmed Abstract
In a Randomized Trial in Prostate Cancer Patients, Dietary Protein Restriction Modifies Markers of Leptin and Insulin Signaling in Plasma Extracellular Vesicles

Eitan E, Tosti V, Suire CN, Cava E, Berkowitz S, Bertozzi B, Raefsky SM, Veronese N, Spangler R, Spelta F, Mustapic M, Kapogiannis D, Mattson MP, Fontana L.
Aging Cell. 2017 Dec; 16(6): 1430-3.

Pubmed Abstract
Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being. Gerontology

Bertozzi B, Tosti V, Fontana L.
Gerontology. 2017; 63(1): 13-9. (Epub 2016 May 14.)

Pubmed Abstract
Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism are Associated with Protein Ingestion-Induced Insulin Resistance

Harris LLS, Smith GI, Patterson BW, Ramaswamy RS, Okunade A, Kelly SC, Porter LC, Klein S, Yoshino J, Mittendorfer B:
Diabetes 2017 (PMID: 28473464)

Pubmed Abstract
Dietary protein, aging and nutritional geometry

Simpson SJ, Le Couteur DG, Raubenheimer D, Solon Biet SM, Cooney GJ, Cogger VC, Fontana L.
Aging Research Reviews. 2017 Oct; 39:78-86.

Pubmed Abstract
Calorie Restriction in Humans: An Update

Most J, Tosti V, Redman LM, Fonana L.
Aging Research Reviews 2017 Oct; 39: 36-45. (Epub 2016 Aug 17.)

Pubmed Abstract
Renal and Systemic Effects of Calorie Restriction in Type 2 Diabetes With Abdominal Obesity: A Randomized Controlled Trial

Ruggenenti P, Abbate M, Ruggiero B, Rota S, Trillini M, Aparicio C, Parvanova A, Iliev IP, Pisanu G, Perna A, Russo A, Diadei O, Martinetti D, Cannata A, Carrara F, Ferrari S, Stucchi N, Remuzzi G, Fontana L.
Diabetes. 2017 Jan; 66(1): 75-86. (Epub 2016 Sep 15.).

Pubmed Abstract
Gnotobiotic Mouse Models for Identifying Consistent Effects of Different Nutritional Lifestyles on the Gut Microbiota of Multiple Unrelated Humans

Griffin NW, Ahern PP, Cheng J, Heath AC, Fontana L, Gordon JI.
Cell Host and Microbe. 2017: 21(1): 84-96.
A Simple Culture System for Long-Term Imaging of Individual C. Elegans

Pittman WE, Sinha DB, Zhang WB, Kinser HE & Pincus Z.
Lab Chip. 2017; 77, 71 (2017). (open access available 2018-11-07.)

Pubmed Abstract
Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice

Lamming DW, Baar EL, Arriola Apelo SI, Tosti V, Fontana L.
Nutrition and Healthy Aging. 2017 Dec 7; 4(3):239-45.

Pubmed Abstract

2016 Publications

Successful Completion of the Pilot Phase of a Randomized Controlled Trial Comparing Sentinel Lymph Node Biopsy to No Further Axillary Staging in Patients with Clinical T1-T2 N0 Breast Cancer and Normal Axillary Ultrasound

Cyr AE, Tucker N, Ademuyiwa F et al. J Am Coll Surg.2016 Aug;223(2):399-407.

Pubmed Abstract
Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36

Love-Gregory L, Kraia AT, Allum F et al. J Lipid Res. 2016 Dec57(12):2176-84.

Pubmed Abstract
Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health

Zhang WB, Sinha DB, Pittman WE, Hvatum E, Stroustrup N, Pincus Z.
Cell Systems, 2016 Oct 26;3(4):333-45.

Pubmed Abstract
NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice

Stromsdorfer KL, Yamaguchi S, Yoon MJ, Moseley AC, Franczyk MP, Kelly SC, Qi N, Imai S, Yoshino J. Cell Reports. 2016 Aug 16;16(7):1851-60.

Pubmed Abstract
Cerebrospinal Fluid Biomarkers and Reserve Variables as Predictors of Future "Non-Cognitive" Outcomes of Alzheimer's Disease

Ingber AP, Hassenstab J, Fagan AM, Benzinger TL, Grant EA, Holtzman DM, Morris JC, Roe CM. J Alzheimers Dis. 2016;52(3):1055-64.

Pubmed Abstract
Human Metabolome-Derived Cofactors are Required for the Antibacterial Activity of Siderocalin in Urine

Shields-Cutler RR, Crowley JR, Miller CD, Stapleton AE, Cui W, Henderson JP.
The Journal of Biological Chemistry. 2016 Oct. 25.

Pubmed Abstract
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle

Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L. Cell Reports. 2016 Jan 26;14(3):422-8.

Pubmed Abstract
Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

Fontana L, Cummings NE, Arriola Apelo SI et al. Cell Reports, 2016 Jul 12;16(2):520-30.

Pubmed Abstract
Calorie restriction in humans: An update

Most J, Tosti V, Redman LM, Fontana L.
Ageing Res Rev., 2016 Aug 17.

Pubmed Abstract
High-protein intake during weight-loss therapy eliminates the weight loss-induced improvement in insulin action in obese postmenopausal women

Smith GI, Yoshino J, Kelly SC, Reeds DN, Okunade A, Patterson BW, Klein S, Mittendorfer B. Cell Reports. Oct. 11, 2016.

Pubmed Abstract
Predicting all-cause mortality from basic physiology in the Framingham Heart Study

Zhang WB, Pincus Z. Aging Cell, 2016 Feb 15. (1):39-48.

Pubmed Abstract
Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity

Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC, de Las Fuentes L, He S, Okunade AL, Patterson BW, Klein S.
Cell Metabolism, 2016 Feb 22. pii: S1550-4131(16)30053-5. doi: 10.1016/j.cmet.2016.02.005. [Epub ahead of print]

Pubmed Abstract | Paper
Probiotic Gut Bacteria Enhance Cancer Immunotherapy in a Mouse Model of Melanoma

Dey N, Ciorba MA.
Gastroenterology. 2016 May 26. pii: S0016-5085(16)34458-4. doi: 10.1053/j.gastro.2016.05.015. [Epub ahead of print] No abstract available.

Pubmed Abstract
Long-Term Administration of Nicotinamide Mononucleotide Mitigates
Age-Associated Physiological Decline in Mice

Kathryn F. Mills, Shohei Yoshida, Liana R. Stein, ..., Koji Uchida,
Jun Yoshino, Shin-ichiro Imai
Cell Metabolism, December 13, 2016 , 24, 1–12 [Epub ahead of print]

Pubmed Abstract
Combined associations of body weight and lifestyle factors with all-cause and cause-sepcific mortality in men and women: prospective cohort study

Veronese N, Li Y, Manson JE, Willett WC, Fonana L, Hu FB.
BMJ 2016 Nov. 24; 355.

2015 Publications

Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss

Su X, Magkos F, Zhou D, Eagon JC, Fabbrini E, Okunade AL, Klein S.
Obesity, 2015 Feb; 23(2):329-34

Pubmed Abstract
Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer

Morrissey JJ, Mobley J, Figenshau RS, Vetter J, Bhayani S, Kharasch ED
Mayo Clinic Proceedings, 2015 Jan; 90(1):35-42

Pubmed Abstract
Evaluation of urine aquaporin-1 and perilipin-2 concentrations as biomarkers to screen for renal cell carcinoma: A prospective cohort study

Morrissey JJ, Mellnick VM, Luo J, Siegel MJ, Figenshau RS, Bhayani S, Kharasch ED
JAMA Oncology, 2015 May; 1(2):204-12

Pubmed Abstract
Human urinary composition controls antibacterial activity of siderocalin

Shields-Cutler RR, Crowley JR, Hung CS, Stapleton AE, Aldrich CC, Marschall J, Henderson JP
The Journal of Biological Chemistry, 2015 April 10,

A bstract
Promoting health and longevity through diet: from model organisms to humans

Fontana L, Partridge L
Cell, 2015 March 25; 161(1); 106-18

Abstract
Calorie restriction, endothelial function and b¬lood pressure homeostasis

Spelta F, Bertozzi B, Cominacini L, Fontana L
Vascul Pharmacol, 2015 Feb-Mar, 65-6:1-2.

Pubmed abstract
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

Levine M, Suarez J, Brandhorst S, Balasubramanian, Cheng CW, Madia F, Fontana L, Mirisola MP, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins E, Longo VD
Cell Metabolism 2014 Mar 4;19(3):407–17

Pubmed abstract
Probiotics to prevent gastrointestinal toxicity from cancer therapy: an interpretive review and call to action

Ciorba MA, Hallemeier CL, Stenson WF, Parikh PJ.
Curr Opin Support Palliat Care. 2015 Jun;9(2):157-62. doi: 10.1097/SPC.0000000000000134. Review.
PMID: 25872116

Pubmed Abstract
Network Analysis Reveals Sex- and Antibiotic Resistance-Associated Antivirulence Targets in Clinical Uropathogens

Parker KS, Wilson JD, Marschall J, Mucha PJ, Henderson JP.
ACS Infect Dis. 2015 Nov 13;1(11):523-32.
“Noncognitive” symptoms of early Alzheimer disease: a longitudinal analysis

Masters MC, Morris JC, Roe CM.
Neurology. 2015 Feb. 10; 84(6): 617-22.
Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

Lamming DW, Cummings NE, Rastelli AL, Gao F, Cava E, Bertozzi B, Spelta F, Pili R, Fontana L. Oncotarget. 2015 Oct 13; 6(31): 31233-40.

Pubmed Abstract
Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.
Aging Cell. 2015 Apr 22; 14(4):497-510.

Pubmed Abstract

2014 Publications

Energy requirements in nonobese men and women: results from CALERIE

Redman LM, Kraus WE, Bhapkar M, Das SK, Racette SB, Martin CK, Fontana L, Wong WW, Robert SB, Ravussin E, for the CALERIE Study Group
Am J Clin Nutr Jan 2014

AJCN abstract
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

Levine ME, Suarez JA, Brandhorst S, Balasubramanian P; Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo, VD
Cell Metabolism 19, 407-17, March 4, 2014

Article
Optimal body weight for health and longevity: bridging basic, clinical, and population research

Fontana L, Hu FB
Aging Cell (2014) pp 1-10

Article
Postprandial plasma incretin hormones in exercise-trained versus untrained subjects

Weiss EP, Royer NK, Fisher JS, Holloszy JO, Fontana L
Med Sci Sports Exerc 2014 Jun; 46(6): 1098-103

Pubmed abstract
Cytochrome P450 gene variants, race and mortality among clopidogrel-treated patients after acute myocardial infarction

Cresci S, Depta JP, Lenzini PA, Li AY, Lanfear DE, Province MA, Spertus JA,. Bach RG
Circ Cardiovasc Genet 2014 Jun;7(3):277-86

Pubmed abstract
Urinary concentrations of aquaporin-1 and perilipin-2 in patients with renal cell carcinoma correlate with tumor size and stage but not grade

Morrissey JJ, Mobley J, Song J, Vetter J, Luo J, Bhayani S, Figenshau RS , Kharasch ED
Urology 2014 Jan;83(1): 256

Pubmed abstract
Activation of miR-9 by human papillomavirus in cervical cancer

Liu W, Gao g,, Hu X, Wang Y, Schwarz JK, Chen JJ, Grigsby PW, Wang X
Oncotarget, 2014 Nov 30; 5(22):11620-30

Pubmed Abstract
CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction

Chen LS, Bach RG, Lenzini PA, Spertus JA, Bierut LJ, Cresci S
Nicotine Tob Res 2014 Sep;16(9):1224-31

Pubmed abstract
What are the roles of calorie restriction and diet quality in promoting healthy longevity?

Rizza W, Veronese N, Fontana L
Ageing Research Reviews 2014 Jan; 13:38-45

Pubmed abstract
Medical research: treat ageing

Fontana L, Kennedy BK, Longo VD, Seals D, Melov S
Nature 2014 Jul 24;511(7510):405-7

Pubmed abstract

2013 Publications

Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later

Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D; Sutphen CL, Benzinger TL, Mintun MA, Holtzman DM, Morris JC
Neurology 2013 May 7;80(19):1784-91

Pubmed abstract
The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma

Morrissey JJ, Kharasch ED
The Journal of Urology, 2013 May; 189(5):1913-20

Pubmed Abstract
Assessing the diagnostic accuracy (DA) of the Spanish version of the informant-based AD8 questionnaire

Carnero Pardo C, de la Vega Cotarelo R, López Alcalde S, Martos Aparicio C, Vilchez Carrillo R, Mora Gavilán E, Galvin JE
Neurologia 2013 Mar;28(2):88-94

Pubmed abstract (in English)
“Deficiency” of mitochondria in muscle does not cause insulin resistance

Holloszy JO
Diabetes 2013 Apr;62 (4): 1036-40

Pubmed abstract
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L
Aging Cell 2013 Aug;12(4):645-51

Pubmed abstract
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model

Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD
Aging Cell 2013 Apr;12(2):257-68

Pubmed abstract
Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients

Fontana L, Addante F, Copetti M, Paroni G, Fontana A, Sancarlo D, Pellegrini F, Ferrucci L, Pilotto A
Aging Cell 2013 Jun;12(3):459-66

Pubmed abstract
Will calorie restriction work in humans?

Cava E, Fontana L
Aging 2013 Jul;5(7):507-14

Pubmed abstract
Serum from humans on long-term calorie restriction enhances stress resistance in cell culture

Omodei D, Licastro D, Salvatore F, Crosby SD, Fontana L
Aging 2013 Aug;5(8):599-606

Pubmed abstract
Energy efficiency as a unifying principle for human, environmental, and global health

Fontana L, Atella V, Kammen DM
F1000Research 2013, 2:101

Pubmed abstract
Multiple dietary supplements do not affect metabolic and cardiovascular health

Soare A, Weiss EP, Holloszy JO, Fontana L
Aging 2013 Sep 4 (Epub)

Pubmed abstract
Dietary protein restriction inhibits tumor growth in human xenograft models

Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo VD, Nguyen H, Vessella R, Pili R
Oncotarget 2013 Dec;4(12):2451-61

Pubmed abstract
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals

Fabbrini E, Cella M, McCartney SA, Fuchs A, Abumrad NA, Pietka TA, Chen Z, Finck BN, Han DH, Magkos F, Conte C, Bradley D, Fraterrigo G, Eagon JC, Patterson BW, Colonna M, Klein S
Gastroenterology 2013 Aug;145(2):366-74

Pubmed abstract
CSF biomarkers of Alzheimer disease: “noncognitive” outcomes

Roe CM, Fagan AM, Grant EA, Holtzman DM, Morris JC
Neurology 2013 Dec 3;81(23):2028-31

Pubmed abstract
Accurate measurement of nicotinamide adenine dinucleotide (NAD+) with high-performance liquid chromatography

Yoshino J, Imai S
Methods Mol Biol 2013;1077:203-15

Pubmed abstract

2012 Publications

An exploration of salivation patterns in normal weight and obese children

Aspen VA, Stein RI, Wilfley DE
Appetite 2012 Apr 58(2):539-42

Pubmed abstract
Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults

Villareal DT, Smith GI, Shah K, Mittendorfer B
Obesity 2012 Sep;20 (9):1780-6

Pubmed abstract
Adrenergic-pathway gene variants influence beta-blocker-related outcomes after acute coronary syndrome in a race-specific manner

Cresci S, Dorn GW 2nd, Jones PG, Beitelshees, AL, Li AY, Lenzini PA, Province MA, Spertus JA, Lanfear DE
Journal of the American College of Cardiology 2012 Sep 4;60(10):898-907

Pubmed abstract
Growth factors, nutrient signaling, and cardiovascular aging

Fontana L, Vinciguerra M, Longo VD
Circulation Research 2012 Apr 13;110(8):1139-50

Pubmed abstract
Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss as compared to calorie restriction

Murphy JC, McDaniel JL, Mora K, Villareal DT, Fontana L, Weiss EP
Journal of Applied Physiology 2012 Jan;112(1):79-85

Pubmed abstract
Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis

Paroni G, Seripa D, Panza F, Addante F, Copetti M, D'Onofrio G, Pellegrini F, Fontana L, Pilotto A
Age (Dordr) 2012 Aug;34(4):949-68

Pubmed abstract
Sexually dimorphic effect of aging on skeletal muscle protein synthesis

Smith GI, Reeds DN, Hall AM, Chambers KT, Finck BN, Mittendorfer B
Biology of Sex Differences 2012 May 23;3(1):11

Pubmed abstract
Caloric restriction may reverse age-related autonomic decline in humans

Stein PK, Soare A, Meyer TE, Cangemi R, Holloszy JO, Fontana L
Aging Cell 2012 Aug;11(4):644-50

Pubmed abstract
Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness

Weiss EP, Villareal DT, Ehsani AA, Fontana L, Holloszy JO
Aging Cell 2012 Oct;11(5):876-84

Pubmed abstract
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance

Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, Gu CC, Kunz I, Rossi Fanelli F, Patterson BW, Klein S
Cell Metabolism 2012 Nov 7;16(5):658-64

Pubmed abstract
[The reliability and validity of Chinese version of AD8]. (article in Chinese)

Li T, Wang HL, Yang YH, Galvin JE, Morris JC, Yu X
Zhonghua Nei Ke Za Zhi 2012 Oct;51(10):777-80

Pubmed abstract (in English)
Predicting road test performance in adults with cognitive or visual impairment referred to a Veterans Affairs Medical Center driving clinic

Niewoehner PM, Henderson RR, Dalchow J, Beardsley TL, Stern RA, Carr DB
Journal of the American Geriatric Society 2012 Nov;60(11):2070-4

Pubmed abstract

2011 Publications

Ginseng and ginsenoside re do not improve ß-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes

Reeds DN, Holloszy JO, Patterson BW, Polonsky KS, Okunade A, Klein S
Diabetes Care Volume 34, May 2011 1071-6

Article
Intermittent supplementation with rapamycin as a dietary restriction mimetic

Longo VD, Fontana L
Aging (Albany NY) 2011 Nov;3(11):1039-40

Pubmed abstract
Application of AD8 questionnaire to screen very mild dementia in Taiwanese

Yang YH, Galvin JE, Morris JC, Lai CL, Chou MC, Liu CK
American Journal of Alzheimer’s Disease & Other Dementias 2011 Mar;26(2):134-8

Pubmed abstract
Caloric restriction: powerful protection for the aging heart and vasculature

Weiss EP, Fontana L
American Journal of Physiology – Heart and Circulatory Physiology 2011 Oct;301(4):H1205-19

Pubmed abstract
Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, obese, older adults

Villareal DT, Smith GI, Sinacore DR, Shah K, Mittendorfer B
Obesity 2011 Feb;19(2):312-8

Pubmed abstract
Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial

Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B
American Journal of Clinical Nutrition 2011 Feb;93(2):402-12

Pubmed abstract
Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women

Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B
Clinical Science (London, England) 2011 Sep;121(6):267-78

Pubmed abstract
Calorie restriction and prevention of age-associated chronic disease

Omodei D, Fontana L
FEBS Letters 2011 Jun 6;585(11):1537-42

Pubmed abstract
Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition

Villareal DT, Kotyk J,J Armamento-Villareal RC, Kenguva V, Seaman P, Shahar A, Wald MJ, Kleerekoper M, Fontana L
Aging Cell 2011 Feb; 10(1):96-102

Pubmed abstract
Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans

Soare A, Cangemi R, Omodei D, Holloszy JO, Fontana L
Aging 2011 Apr;3(4):374-9

Pubmed abstract
Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial

Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye RL, Bach RG; BARI 2D Study Group
Circulation 2011 Sep 27;124(13):1426-34

Pubmed abstract
Dementia screening, biomarkers and protein misfolding: Implications for public health and diagnosis

Galvin JE
Prion 2011 Jan-Mar;5(1):16-21

Pubmed abstract
AD8-Brazil: cross-cultural validation of the ascertaining dementia interview in Portuguese

Correia CC, Lima F, Junqueira F, Campos MS, Bastos O, Petribú K, Laks J, Galvin JE
Journal of Alzheimer’s Disease.2011;27(1):177-85

Pubmed abstract
Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosysthesis

Imai S
FEBS Lett 2011 Jun 6;585(11): 1657-62

Pubmed abstract
Predicting road test performance in drivers with dementia

Carr DB, Barco PP, Wallendorf MJ, Snellgrove CA, Ott BR
Journal of the American Geriatric Society 2011 Nov;59(11):2112-7

Pubmed abstract
Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Yoshino J, Mills KF, Yoon JY and Imai S.
Cell Metab. 2011 Oct 5;14(4):528-36.

Pubmed abstract

2010 Publications

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

Imai S, Guarente L
Trends Pharmacol Sci 2010 May;31(5):212-20

Pubmed abstract
Relationship of dementia screening tests with biomarkers of Alzheimer's disease

Galvin JE, Fagan AM, Holtzman DM, Mintun MA, Morris JC
Brain. 2010 Nov;133(11):3290-300

Pubmed abstract
A microRNA expression signature for cervical cancer prognosis

Hu X, Schwarz JK, Lewis JS Jr, Huettner PC, Rader JS, Deasy JO, Grigsby PW, Wang X
Cancer Research 2010 Feb 15;70(4):1441-8

Pubmed abstract
Extending healthy life span – from yeast to humans

Fontana L, Partridge L, Longo VD
Science 2010 Apr 16;328(5976):321-6

Pubmed abstract
Long-term effects of calorie restriction on serum sex-hormone concentrations in men

Cangemi R, Friedmann, AJ, Holloszy JO, Fontana L
Aging Cell 2010 Apr;9(2):236-42

Pubmed abstract
Calorie restriction and cancer prevention: metabolic and molecular mechanisms

Longo VD, Fontana L
Trends in Pharmacological Sciences 2010 Feb;31(2):89-98

Pubmed abstract
Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production

Fontana L, Klein S, Holloszy JO
Age 2010 Mar;32(1):97–108

Pubmed abstract
TRB3 function in cardiac endoplasmic reticulum stress

Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ
Circulation Research 2010 May 14;106(9):1516-23

Pubmed abstract
A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis

Imai, S
Pharmacological Research 2010 Jul;62(1):42-7

Pubmed abstract
Organizational support and volunteering benefits for older adults

Tang F, Choi E, Morrow-Howell N
The Gerontologist 2010 Oct;50(5):603-12

Pubmed abstract

2009 Publications

Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction

Fontana L
Experimental Gerontology 2009 Jan-Feb;44(1-2):41-5

Pubmed abstract
“Clocks” in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging

Imai, S
Biochimica et Biophysica Acta 2010 Aug;1804(8):1584-90

Pubmed abstract
Driving retirement in older adults with dementia

Croston J, Meuser TM, Berg-Weger M, Grant EA, Carr DB
Topics in Geriatric Rehabilitation 2009 Apr 1;25(2): 154-62

Pubmed abstract
The scientific basis of caloric restriction leading to longer life

Fontana L
Current Opinion in Gastroenterology 2009 Mar;25(2):144-50

Pubmed abstract
Modulating human aging and age-associated diseases

Fontana L
Biochimca et Biophysica Acta 2009 Oct;1790 (10):1133-8

Pubmed abstract
SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty

Imai S
Current Opinion in Clinical Nutrition and Metabolic Care 2009 Jul;12(4):350-6

Pubmed abstract
Who benefits from volunteering: Variations in perceived benefits

Morrow-Howell N, Hong SI, Tang F
The Gerontologist 2009 Feb;49 (1):91-102

Pubmed abstract
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C,Takahashi JS, Imai S, Bass J
Science 2009 May 1;324(5927): 651-4

Pubmed abstract

2008 Publications

MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets

Muslin AJ
Clinical Science (London, England) 2008 Oct;115(7):203-18

Pubmed abstract
The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan

Collins JJ, Evason K, Pickett CL, Schneider DL, Kornfeld K
PLoS Genetics 2008 Oct;4(10): e1000230

Pubmed abstract
The measurement and analysis of age-related changes in Caenorhabditis elegans

Collins JJ, Huang C, Hughes S, Kornfeld K
WormBook 2008 Jan 24:1-21

Pubmed abstract
Reduction of overweight and eating disorder symptoms via the Internet in adolescents: A randomized controlled trial

Doyle AC, Goldschmidt A, Huang C, Winzelberg AJ, Taylor CB, Wilfley DE
Journal of Adolescent Health 2008 Aug;43 (2): 172-9

Pubmed abstract
Valproic acid extends Caenorhabditis elegans lifespan

Evason K, Collins JJ, Huang C, Hughes S, Kornfeld K
Aging Cell 2008 Jun;7(3):305-17

Pubmed abstract
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans

Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO
Aging Cell 2008 Oct;7(5):681-7

Pubmed abstract
Translational approaches to addressing complex genetic pathways in colorectal cancer

Early DS, Fontana L, Davidson NO
Translational Research 2008 Jan;151(1):10-6

Pubmed abstract
Calorie restriction and cardiometabolic health

Fontana L
European Journal of Cardiovascular Prevention and Rehabilitation 2008 Feb;15(1):3-9

Pubmed abstract
Changes in weight and health behaviors from freshman through senior year of college

Racette, SB, Deusinger SS, Strube MJ, Highstein GR, Deusinger RH
J Nutr Educ Behav 2008 Jan-Feb;40(1):39-42

Pubmed abstract

2007 Publications

Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk

Fontana L, Meyer TE, Klein S. Holloszy JO
Rejuvenation Res 2007 Jun;10(2):225-34

Pubmed abstract
Aging, adiposity and calorie restriction

Fontana L, Klein S
JAMA 2007 Mar 7;297(9):986-94

Pubmed abstract
Evaluation of cognitive impairment in older adults: combining brief informant and performance measures

Galvin JE, Roe CM, Morris JC
Archives of Neurology 2007 May,64(5):718-24

Pubmed abstract
Patient’s rating of cognitive ability: using the AD8, a brief informant interview, as a self-rating tool to detect dementia

Galvin JE, Roe CM, Coats MA, Morris JC
Archives of Neurology 2007 May;64(5):725-30

Pubmed abstract
Quantifying the usefulness of CT in evaluating seniors with abdominal pain

Lewis LM, Klippel AP, Bavolek RA, Ross LM, Scherer TM, Banet GA
European Journal of Radiology 2007 Feb;61(2):290-6

Pubmed abstract
Productive engagement and late life physical and mental health: Findings from a nationally representative panel study

Hinterlong JE, Morrow-Howell N, Rozario PA
Research on Aging 2007 Jul;29(4):348-70

Abstract

2006 Publications

Effects of anticonvulsant drugs on life span

Kornfeld K, Evason K
Archives of Neurology 2006 Apr;63(4):491-6

Pubmed abstract | Full Text
Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans

Collins JJ, Evason K, Kornfeld K
Experimental Gerontology 2006 Oct;41(10):1032-9

Pubmed abstract
Validity and reliability of the AD8 informant interview in dementia

Galvin JE, Roe CM, Xiong C, Morris JC
Neurology 2006 Dec 12;67(11):1942-8

Pubmed abstract
Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults

Villareal DT, Miller BV III, Banks M, Fontana L, Sinacore DR, Klein S
The American Journal of Clinical Nutrition 2006 Dec;84(6):1317–23

Pubmed abstract

2005 Publications

Anticonvulsant medications extend worm life-span

Evason K, Huang C, Yamben I, Covey DF, Kornfeld K
Science 2005 Jan 14;307(5707):258-62

Pubmed abstract | Free Text (with registration)
The AD8: a brief informant interview to detect dementia

Galvin JE, Roe CM, Powlishta KK, Coats MA, Muich SJ, Grant E, Miller JP, Storandt M, Morris JC
Neurology 2005 Aug 23;65(4):559-64

Pubmed abstract
Obesity in older adults: Technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society

Villareal DT, Apovian CM, Kushner RF, Klein S
Obesity Research 2005 Nov;13(11):1849-63

Pubmed abstract

2003 Publications

Effects of volunteering on the well-being of older adults

Morrow-Howell N, Hinterlong J, Rozario PA, Tang F
The Journal of Gerontology Series B, Psychological Sciences and Social Sciences. 2003 May;58(3):S137-45

Pubmed abstract
Predictors of mortality in younger and older patients with heart failure and preserved or reduced left ventricular ejection fraction

Kerzner R, Gage BF, Freedland KE, Rich MW
American Heart Journal 2003 Aug;146(2):286-90

Pubmed abstract
Identifying factors associated with disability-related differences in breast cancer screening (United States)

Schootman M, Jeffe DB
Cancer Causes and Control 2003 Mar;14(2):97-107

Pubmed abstract

Publications

Investigations funded by the Longer Life Foundation have resulted to date in 151 articles in peer-reviewed medical journals. Find them here.

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2016 Publications

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