Research

Grants by the Longer Life Foundation have supported hundreds of academicians and scientists engaged in fundamental research into longevity and health.

LLF-supported research investigations produce groundbreaking results as well as substantial subsequent support by major research institutions.
Since LLF’s founding in 1998:
100   
investigations
have been funded.
106  
peer-reviewed research articles have
been published, citing LLF support.

LLF also funds the Longevity Research Program, which studies the physiological effects of ongoing calorie restriction upon the human body and analyzes the implications of its findings for aging and longevity.

View All Longer Life Foundation Grants

Grants 2016

  • Awarded: 2016

    Citrulline as Potential Insulin Sensitizer and Longevity Factor


    Thomas J. Baranski, M.D., Ph.D.  

    Investigation Year: 1st Year

  • Awarded: 2016

    The Impact of Progressive Telomere Shortening on Mitochondria Function and Energy Metabolism


    Luis Batista, Ph.D.

    Investigation Year:  1st Year

  • Awarded: 2016

    Age-Specific Mechanisms Drive the Pathogenesis of Human Heart Failure


    Kory Lavine, M.D., Ph.D.

    Investigation Year:  1st Year

  • Awarded: 2016

    Identification of Novel Blood Biomarkers and Mediators of Obesity-Induced Insulin Resistance


    Jun Yoshino, M.D., Ph.D.

    Investigation Year: 2nd Year

  • Awarded: 2016

    Identification of Human Genetic Variants for High Risk of Severe Influenza Disease

     


     

    Adrianus Boon, Ph.D. 

    Investigation Year: 2nd Year

  • Awarded: 2016

    Remote Detection of TP53 and ß-catenin Mutations in Liver Cancer


    Yiing Lin, M.D., Ph.D.

    Investigation Year:  2nd Year

  • Awarded: 2016

    Using Anti-Viral Biomarkers to Predict Breast Cancer Aggressiveness


    Jason Weber, Ph.D.

    Investigation Year: 2nd Year

  • Awarded: 2016

    Metabolic and Molecular Effects of Intermittent Fasting and Mediterranean Diet


    Longevity Research Program:
    Luigi Fontana, M.D., Ph.D.

    Investigation Year: 1st Year


     

Grants 2015

  • Awarded: 2015

    Long-Term Health Benefits of Caloric Restriction: Does Intermittent Fasting Mimic the Anti-Aging and Health Benefits of Calorie Restriction in Humans?


    Longevity Research Program:
    John Holloszy, M.D., Director 
    Luigi Fontana, M.D. Ph.D., Assoc. Dir.

    Investigation Year: 2nd Year

  • Awarded: 2015

    Functional Dissection of Age-Related Differences in Disease Phenotype in Polycythemia Vera


    Stephen Oh, M.D., Ph.D.

    Investigation Year:  1st Year

  • Awarded: 2015

    Using Anti-Viral Biomarkers to Predict Breast Cancer Aggressiveness


    Jason D. Weber, Ph.D.  

    Investigation Year:  1st Year

  • Awarded: 2015

    Identification of Novel Blood Biomarkers and Mediators of Obesity-Induced Insulin Resistance


    Jun Yoshino, M.D., Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2015

    Early-Adulthood Predictors of Mortality and Morbidity


    Zachary Pincus, Ph.D. 

    Investigation Year: 1st Year

  • Awarded: 2015

    snoRNAs and Long-Term Risk of Diabetic Complications


    Jean E. Schaffer, M.D.

    Investigation Year:   2nd Year

  • Awarded: 2015

    A Randomized Control Trial of the Probiotic LGG for Prevention of Side Effects in Patients Undergoing Chemoradiation for Gastrointestinal Cancer


    Matt Ciorba, M.D. 

    Investigation Year: 2nd Year

  • Awarded: 2015

    Identification of Human Genetic Variants for High Risk of Severe Influenza Disease


    Adrianus Boon, Ph.D. 

    Investigation Year:  1st Year

Grants 2014

  • Awarded: 2014

    Long-Term Health Benefits of Caloric Restriction: Does Intermittent Fasting Mimic the Anti-Aging and Health Benefits of Calorie Restriction in Humans?


    Longevity Research Program:
    John Holloszy, M.D., Director
    Luigi Fontana, M.D. Ph.D., Associate Director

    Investigation Year:  1st Year

  • Awarded: 2014

    A Prospective, Randomized Trial of Sentinel Lymph Node Biopsy Versus No Additional Staging in Patients with Clinical T1-2 N0M0 Invasive Breast Cancer and Negative Axillary Ultrasound


    Amy E. Cyr, M.D.

    Investigation Year:   2nd Year

  • Awarded: 2014

    Discovery of Urinary Tract Infection Biomarkers to Predict Longevity in the Elderly


    Jeffrey Henderson, M.D. Ph.D. 

    Investigation Year:   2nd Year

  • Awarded: 2014

    Effect of Dietary Macronutrient Composition on Glycemic Control and Cardiovascular Risk Factors


    Dominic N. Reeds, M.D.

    Investigation Year: 2nd Year

  • Awarded: 2014

    Plasma DNA Mutations as Biomarkers of Hepatocellular Carcinoma


    Yiing Lin, M.D. Ph.D. 

    Investigation Year: 1st Year

  • Awarded: 2014

    snoRNAs and Long-Term Risk of Diabetic Complications


    Jean E. Schaffer, M.D.

    Investigation Year: 1st Year

  • Awarded: 2014

    Prognostic and Therapeutic Value of Nuclear pSer137-Pfn1 for Breast Cancer


    Jieya Shao, Ph.D.

    Investigation Year:  1st Year

Grants 2013

  • Awarded: 2013

    Long-Term Health Benefits of Calorie Restriction; Does a Low-Protein Diet Slow Aging, Protect Against Cancer and Inhibit Prostate Cancer Growth?


    Longevity Research Program:
    John Holloszy M.D., Director
    Luigi Fontana M.D., Ph.D., Associate Director

    Investigation Year:  4th Year

  • Awarded: 2013

    A Prospective, Randomized Trial of Sentinel Lymph Node Biopsy Versus No Additional Staging in Patients with Clinical T1-2 N0 M0 Invasive Breast Cancer and Negative Axillary Ultrasound


    Amy E. Cyr, M.D.

    Investigation Year:  2nd Year

  • Awarded: 2013

    Discovery of Urinary Tract Infection Biomarkers to Predict Longevity in the Elderly


    Jeffrey Henderson, M.D. Ph.D.

    Investigation Year:  1st Year

  • Awarded: 2013

    Long-Term Prognostic Values of Novel Cardiac Biomarkers After Cardiac Stress Echocardiography (Testing)


    Peter Nagele, M.D.

    Investigation Year: 1st Year

  • Awarded: 2013

    Effects of Dietary Macronutrient Composition on Glycemic Control and Cardiovascular Risk Factors


    Dominic N. Reeds, M.D.

    Investigation Year: 2nd Year

Grants 2012

  • Awarded: 2012

    Long-Term Health Benefits of Calorie Restriction; Does a Low-Protein Diet Slow Aging, Protect Against Cancer and Inhibit Prostate Cancer Growth?


    Longevity Research Program:
    John Holloszy M.D., Director
    Luigi Fontana M.D., Ph.D., Associate Director

    Investigation Year:  3rd Year

  • Awarded: 2012

    A Randomized Control Trial of the Probiotic LGG for Prevention of Side Effects in Patients Undergoing Chemoradiation for Gastrointestional Cancer


    Matt Ciorba, M.D.

    Investigation Year:  2nd Year

  • Awarded: 2012

    CD36 Variants and Stroke Risk Factors 


    Latisha Love-Gregory, Ph.D.

    Investigation Year: 2nd Year

  • Awarded: 2012

    A Pilot Study of Adipokines and Caloric Restriction in Patients with Multiple Sclerosis


    Laura Piccio, M.D., Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2012

    Use of Alzheimer's Disease Biomarkers to Predict Longevity and Disability


    Catherine Roe, Ph.D.

    Investigation Year: 2nd Year

  • Awarded: 2012

    Monomethyl Branched Chain Fatty Acids (mmBCFAs) as Potential Biomarkers for Risk of Obesity-Associated Metabolic Disease


    Xiong Su, Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2012

    Effects of Increased Dietary High-Fructose Corn Syrup on Intrahepatic Triglyceride Content and Lipoprotein Kinetics in People with a Non-Alcoholic Fatty Liver Disease


    Shelby Sullivan, M.D.

    Investigation Year: 2nd Year

  • Awarded: 2012

    Is Aging and its Associated Co-morbidities Due to Diminished Autophagy?


    Conrad Weihl, M.D., Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2012

    Survival, Disease Co-morbidity, and Assessment of Novel and Genetic Variants for Risk Prediction in the NHLBI Family Heart Study (FamHS)


    Mary Kaye Wojczynski, Ph.D.

    Investigation Year: 1st Year

Grants 2011

  • Awarded: 2011

    Does a Low-Protein Diet Slow Aging, Protect Against Cancer and Inhibit Prostate Cancer Growth?


    Longevity Research Program:
    John Holloszy M.D., Director
    Luigi Fontana M.D., Ph.D., Associate Director

    Investigation Year: 2nd Year

  • Awarded: 2011

    Determination of the Genetic Contribution to Glycemic Control and CAD Outcomes in Patients with DM2 and CAD


    Sharon Cresci, M.D.

    Investigation Year: 2nd Year

  • Awarded: 2011

    Assessment of Potential Novel Immune Biomarkers to Identify Obese Persons at Increased Risk for Cardiometabolic Disease


    Elisa Fabbrini, M.D., Ph.D.

    Investigation Year: 2nd Year

  • Awarded: 2011

    CD36 Variants and Stroke Risk Factors


    Latisha Love-Gregory, Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2011

    Improving Presymptomatic Detection of Impending Alzheimer's Disease


    Catherine Roe, Ph.D.

    Investigation Year: 1st Year

Grants 2010

  • Awarded: 2010

    Does a Low-Protein Diet Slow Aging, Protect Against Cancer and Inhibit Prostate Cancer Growth?


    Longevity Research Program:
    John Holloszy M.D., Director
    Luigi Fontana M.D., Ph.D., Associate Director

    Investigation Year: 1st Year

  • Awarded: 2010

    Predicting Prognosis in Invasive Breast Cancer by Genetic Instability


    D. Craig Allred, M.D.

    Investigation Year: 1st Year

  • Awarded: 2010

    Does Caloric Restriction Slow Aging of the Human Immune System?


    Marco Colonna, M.D.

    Investigation Year: 2nd Year

  • Awarded: 2010

    Determination of the Genetic Contribution to Glycemic Control and CAD Outcomes in Patients with DM2 and CAD


    Sharon Cresci, M.D.

    Investigation Year: 1st Year

  • Awarded: 2010

    Assessment of Potential Novel Immune Biomarkers to Identify Obese Persons at Increased Risk for Cardiometabolic Disease


    Elisa Fabbrini, M.D., Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2010

    Calorie Restriction and Metabolic Health in Older Adults


    Bettina Mittendorfer, Ph.D.

    Investigation Year: 1st Year

Grants 2009

  • Awarded: 2009

    Longer Life Foundation Longevity Research Program


    John Holloszy M.D., Director
    Luigi Fontana M.D., Ph.D., Associate Director

    Investigation Year: 2nd Year

  • Awarded: 2009

    Does Caloric Restriction Slow Aging of the Human Immune System?


    Marco Colonna, M.D.

    Investigation Year: 1st Year

  • Awarded: 2009

    Diagnostic and Therapeutic Applications of a Novel Plasma Metabolite, Nicotinamide Mononucleotide (NMN), for Age-Associated Metabolic Complications in Humans


    Shin-ichiro Imai, M.D., Ph.D.

    Investigation Year: 2nd Year

  • Awarded: 2009

    Novel Proteins as Urinary Biomarkers of Renal Cell Carcinoma


    Jeremiah Morrissey, Ph.D. and
    Evan D. Kharasch, M.D., Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2009

    Novel Methods for Detection of Coronary Artery Disease in Diabetic Patients


    Ravi Rasalingam, M.D.

    Investigation Year: 2nd Year

  • Awarded: 2009

    MicroRNA Expression Signatures to Predict Cervical Cancer Outcome


    Xiaowei Wang, Ph.D.

    Investigation Year: 1st Year

Grants 2008

  • Awarded: 2008

    Longer Life Foundation Longevity Research Program


    John Holloszy M.D., Director
    Luigi Fontana M.D., Ph.D., Associate Director

    Investigation Year: 1st Year

  • Awarded: 2008

    Fitness-to-Drive in Older Adults with Stroke


    David B. Carr, M.D.

    Investigation Year:  2nd Year

  • Awarded: 2008

    Diagnostic and Therapeutic Applications of a Novel Plasma Metabolite, Nicotinamide Mononucleotide (NMN), for Age-Associated Metabolic Complications in Humans


    Shin-ichiro Imai, M.D., Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2008

    Modulation of Aging and Calorie Restriction Benefits by PGC-1α


    John J. Lehman, M.D.

    Investigation Year: 1st Year

  • Awarded: 2008

    Omega-3 Fatty Acids for the Treatment of the Anabolic Resistance of Skeletal Muscle in Older Adults


    Bettina Mittendorfer, Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2008

    Identification of Significant Coronary Artery Disease at Rest with Integrated Backscatter Imaging and Myocardial Strain


    Ravi Rasalingan, M.D.

    Investigation Year: 1st Year

Grants 2007

  • Awarded: 2007

    Fitness-to-Drive in Neurologically Impaired Older Adults


    David B. Carr, M.D.

    Investigation Year: 1st Year

  • Awarded: 2007

    Effects of Calorie Restriction on Markers of Aging and Longevity


    Luigi Fontana, M.D. Ph.D.

    Investigation Year: 2nd Year

  • Awarded: 2007

    Undercarboxylated Matrix Gla Protein (ucMGP): a Novel Biomarker to Predict Coronary Artery Calcification


    Tusar K. Giri, M.D., Ph.D.
    Brian F. Gage, M.D. M.Sc.

    Investigation Year: 1st Year

  • Awarded: 2007

    Dependence of Longevity and Health on TRB3 Genotype


    Anthony J. Muslin, M.D.

    Investigation Year: 2nd Year

  • Awarded: 2007

    Comprehensive Assessment of Senior Adult Cancer Patients


    Jay F. Piccirillo, M.D.

    Investigation Year: 1st Year

Grants 2006

  • Awarded: 2006

    Effects of Calorie Restriction on Markers of Aging and Longevity


    Luigi Fontana, M.D., Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2006

    Minimally Invasive Staging of the Axilla in Breast Cancer


    Julie A. Margenthaler, M.D.

    Investigation Year: 1st Year

  • Awarded: 2006

    Dependence of Longevity and Health on TRB3 Genotype


    Anthony J. Muslin, M.D.

    Investigation Year: 1st Year

  • Awarded: 2006

    International Collaborative Study of Social Support


    Edwin B. Fisher, Ph.D.

    Investigation Year: 2nd Year

Grants 2005

  • Awarded: 2005

    Mental Health History and Survival Among Breast Cancer Patients


    Mark S. Walker, Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2005

    Regulation of Longevity by Anticonvulsant Medicines


    S. Kerry Kornfeld, M.D.

    Investigation Year: 1st Year

  • Awarded: 2005

    Activity Portfolios: Engagement and Health in Later Life


    Nancy L. Morrow-Howell, Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2005

    The Effect of the C488&A Polymorphism of the CYP1A1 Gene on Cognitive Function


    Reina C. Villareal, M.D.

    Investigation Year: 1st Year

Mini-Grants 2005

  • Awarded: 2005

    Collection of Preliminary Data on the Interaction of Social Engagement and Stress in Older Adults


    Dorothy Edwards, Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2005

    Environmental Features that Influence Social Engagement of Older Adults Residing in Congregate Living Facilities


    Susan L. Stark, Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2005

    Effects of Allocation of Attention on Habituation to Olfactory and Visual Food Stimuli in Obese Children


    Denise E. Wilfley, Ph.D.

    Investigation Year: 1st Year

Grants 2004

  • Awarded: 2004

    Food For Thought: An Internet-Based Treatment Program for Childhood Obesity


    Jane Garbutt, M.B., Ch.B.

    Investigation Year: 1st Year

  • Awarded: 2004

    Ginseng in Prevention and Treatment of Diabetes


    Kenneth S. Polonsky, M.D.

    Investigation Year: 1st Year

  • Awarded: 2004

    Development of Multidisciplinary Approach to Obesity


    Samuel Klein, M.D.

    Investigation Year: 1st Year

  • Awarded: 2004

    Projecting Individualized Cancer-Specific Death Risks and Other Competing Cause Death Risks Among Elderly Men Diagnosed with Prostate Cancer


    Yan Yan, M.D., M.H.S., Ph.D.

    Investigation Year: 1st Year

Mini-Grants 2004

  • Awarded: 2004

    Inflammatory Cytokines and Physical Frailty in Obese Elderly Subjects


    Dennis T. Villareal, M.D.

    Investigation Year: 1st Year

  • Awarded: 2004

    Early Intervention of Eating- and Weight-Related Problems Via the Internet in Overweight Adolescents: A Randomized Controlled Trial


    Denise E. Wilfley, Ph.D.

    Investigation Year: 1st Year

Grants 2003

  • Awarded: 2003

    International Collaborative Study of Social Support


    Edwin S. Fisher, Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2003

    The Key Features Inventory: Early Diagnosis of Dementia to Improve Quality of Life


    James E. Galvin, M.D.

    Investigation Year: 1st Year

  • Awarded: 2003

    Pharmacologic Compounds that Extend C. elegans Life Span


    S. Kerry Kornfeld, M.D. Ph.D.

    Investigation Year: 1st Year

Mini-Grants 2003

  • Awarded: 2003

    Influence of Exercise and Dietary Patterns on Weight Gain Throughout College


    Susan S. Deusinger, Ph.D.
    Susan B. Racette, Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2003

    Predictors of Survival in Patients with Primary Pulmonary Hypertension Wait-Listed for Lung Transplantation


    Roger D. Yusen, M.D., M.P.H.

    Investigation Year: 1st Year

Mini-Grants 2002

  • Awarded: 2002

    Long-Term Adjustment and Quality of Life Among Breast Cancer Survivors Following Treatment


    Tiffany L. Tibbs, Ph.D.
    Teresa L. Deshields, Ph.D.

    Investigation Year: 1st Year

  • Awarded: 2002

    Physician-Related Barriers to Colorectal Cancer Screening in Missouri


    Dayna S. Early, M.D.

    Investigation Year: 1st Year

  • Awarded: 2002

    Markers of Cognitive Change in an Aging Population


    James E. Galvin, M.D.

    Investigation Year: 1st Year

  • Awarded: 2002

    Psychosocial Factors Associated with Delay in Diagnosis Among Locally Advanced Breast Cancer Patients


    Donna B. Jeffe, Ph.D.

    Investigation Year:  1st Year

  • Awarded: 2002

    Abdominal Pain Evaluation Tool (APET) (Pilot Project)


    Lawrence M. Lewis, M.D.

    Investigation Year: 1st Year

Grants 2001

Grants 2000

Grants 1999