Longer Life Newsletter: September 2022 Issue


Welcome to the September 2022 issue of The Longer Life Foundation newsletter! Our goal is to provide you with periodic updates on the Foundation’s activities. With the 25th anniversary of the Foundation approaching in 2023, activities are increasing and plans are being made for an exciting anniversary year. Please read ... Read More »

Longer Life Newsletter: April 2022 Issue


Welcome to the April 2022 issue of The Longer Life Foundation newsletter.  Our goal is to provide you with periodic updates on the Foundation’s activities. 2022 thus far is shaping up to be a very exciting year for the LLF, with our expanded Grand Rounds sponsorship program as well ... Read More »

Drug mimics beneficial effects of fasting in mice


An investigational cancer drug that starves tumors of their energy supply also shows evidence of improving whole body metabolism, leading to improved weight control, according to a new study in mice from researchers at Washington University School of Medicine in St. Louis. Read More »

Longer Life Newsletter: December 2021 Issue


Welcome to the December 2021 issue of The Longer Life Foundation newsletter! As always, we hope you and your loved ones continue to be healthy and safe. Our goal is to provide you with periodic updates on the Foundation’s activities. 2021 was a year of great activity and 2022 is ... Read More »

Cardiovascular Aging: Causes and Intervention


Aging is defined as a gradual decline in physical and mental capacity, associated with chronic inflammation that results in a progressive decline in the functional performance of multiple organs. More specifically, a ging causes cardiovascular changes, but the rate of biological aging can differ significantly between individuals of the same ... Read More »

Eight researchers receive Longer Life Foundation awards


Eight researchers at Washington University in St. Louis have received funding from the Longer Life Foundation. The grants help junior investigators launch research projects and assist more established researchers as they move their investigations into new areas. The foundation’s mission is to fund and support the study of factors ... Read More »

Predicting Cognitive Decline: Advances in Pre-Clinical Diagnosis of Alzheimer’s Disease


This article is the second in a three-part series, highlighting areas of research funded by the Longer Life Foundation. RGA’s Hilary Henly, Global Medical Researcher, analyzes findings from studies funded by the LLF, looking at the different factors influencing cognitive decline and the new techniques available that are helping ... Read More »

Greig Woodring, a Member of the Longer Life Board of Governors, to be Inducted into the Insurance Hall of Fame


The International Insurance Society (IIS) announced today that A. Greig Woodring, retired president and CEO of Reinsurance Group of America, Incorporated (RGA), will be inducted to the Insurance Hall of Fame in recognition of his lifetime contributions. The Longer Life Foundation was the brainchild of Woodring, and past ... Read More »

Caloric Restriction (CR): What is It and What Does the Research Tell Us?


Preventing non-communicable diseases and promoting healthy aging are both important in improving long-term health and reducing levels of frailty in the elderly. Extensive research in animals shows that a 30-50% calorie restriction (CR) without malnutrition increases lifespan by 30-50% and reduces incidence of chronic diseases. Hilary Henly, ... Read More »

Building better vaccines for the elderly: A Q&A with chemist Meredith Jackrel


Longer Life Foundation Investigator Meredith Jackrel, studies protein misfolding and how it leads to disease. She is collaborating with Jai Rudra at the McKelvey School of Engineering to develop amyloid-inspired vaccine technologies specifically tailored for seniors. Read More »

Longer Life Foundation provides interim grant to Dr. Jeffrey Henderson for COVID-19 research


Jeffrey P. Henderson , MD, PhD, associate professor of medicine and of molecular microbiology at the School of Medicine, has received a $20,000 grant from  the Longer Life Foundation , a cooperative effort between the School of Medicine and the Reinsurance Group of America, to help fund ... Read More »

Childhood Obesity


Longer Life investigator Denise Wilfey of the Washington University in St. Louis Department of Psychiatry at the School of Medicine is senior author of a newly published psychotherapy guide to treat childhood obesity.   Read More »

Can fasting improve MS symptoms?


Longer Life investigator Laura Piccio describes her efforts to research caloric restriction and its effects on multiple sclerosis (MS) symptoms.  Read More »

Longer Life Recipient Kory Lavine Named ASCI 2017 Young Physician-Scientist


Longer Life grant recipient Kory J. Lavine, M.D., Ph.D., of Washington University School of Medicine, was named American Society for Clinical Investigation (ASCI)  2017 Young Physician-Scientist. Dr. Lavine was recognized at the 2017 AAP/ASCI/APSA Joint Meeting and presented work at the ASCI’s Food and Science Evening on April ... Read More »

How This Broccoli Enzyme Can Slow Aging


Researchers have zeroed in on an enzyme — found in natural foods like broccoli and cucumbers — that can slow some of the chronic conditions that come with age. So far the findings are limited to mice, but they’re encouraged enough to start testing it in people Read More »

Natural compound reduces signs of aging in healthy mice


Much of human health hinges on how well the body manufactures and uses energy. For reasons that remain unclear, cells’ ability to produce energy declines with age, prompting scientists to suspect that the steady loss of efficiency in the body’s energy supply chain is a key driver of the aging process. Read More »

High-Protein Diets May Negate Some Of The Benefits Of Losing Weight


There’s been a fair amount of controversy surrounding the benefits of high-protein diets, like Atkins and Paleo, both for weight maintenance and for weight loss. The high-protein diet seems to work pretty well for weight loss in the short term, but the range of its metabolic effects is still ... Read More »

It’s Time to Rethink High-Protein Diets for Weight Loss


Eating a diet that’s high in protein is often recommended for people trying to lose weight, since high-protein foods make people feel more full, preventing overeating. However, a new study suggests that while the diet may help people slim down, it doesn’t necessarily improve other health problems under the hood. (For more on that, see: How Much Protein Should I Eat Every Day.) Read More »

Antibiotic resistance focus of Washington University and national research project


As superbugs capture attention as a worldwide health threat, Washington University will be part of a national campaign against drug-resistant bacteria with a $2 million federal grant.  Read More »



Brittany Franklin wasn’t expecting a diagnosis of ulcerative colitis (UC) at the age of 22. She was just embarking on her adult life, looking forward to a bright future. But when intestinal problems landed her at Barnes-Jewish Hospital, she had to confront a new health reality...    Read More »

Benefits of moderate weight loss in people with obesity


More than one of every three Americans are obese. Obesity is a risk factor for many diseases, including type 2 diabetes and heart disease. These health issues stem from a range of underlying metabolic abnormalities that affect the liver, pancreas, muscle, fat, and other tissues.   Read More »

Big Health Benefits to Small Weight Loss


Obese individuals who lose as little as 5 percent of their body weight can improve their metabolic function and reduce the risk of developing Type 2 diabetes and heart disease, a new study has found. Read More »

Losing Just A Little Weight Can Bring Big Health Benefits


Being overweight isn’t linked only to heart risk (although it is that, too)–it’s connected to a constellation of factors that collectively increase a person’s risk for diabetes, cancer, stroke and even dementia. So losing weight is not by any stretch just about a single body system. Weight loss is important ... Read More »

Local Study Finds Health Benefits in Small Weight Loss


ST. LOUIS (KMOX) – A new local study finds some big health benefits can result from a small amount of weight loss. Washington University researchers, led by Dr. Sam Klein, found that a relatively small weight loss markedly lowered obese patients’ risk for diabetes and cardiovascular disease.   ... Read More »

In obese patients, 5 percent weight loss has significant health benefits


For patients with obesity trying to lose weight, the greatest health benefits come from losing just 5 percent of their body weight, according to a new study at Washington University School of Medicine in St. Louis. Read More »

Diet and urine acidity may have roles in UTI susceptibility


The acidity of urine — as well as the presence of small molecules related to diet — may influence how well bacteria can grow in the urinary tract, a new study shows. The research, at Washington University School of Medicine in St. Louis, may have implications for treating urinary ... Read More »

Gerontology expert works to understand 'whole picture of aging'


Nancy Morrow-Howell , PhD, is a national leader in gerontology, widely known for her work on productive and civic engagement of older adults. She is the Bettie Bofinger Brown Distinguished Professor of Social Policy at the Brown School, faculty director of productive aging research at the  Center ... Read More »

Molecular biologist seeks the keys to healthy aging


As Shin-ichiro Imai grew up outside Tokyo, he heard his parents many times tell the story of his unlikely birth. According to Imai, doctors told his mother there was a high risk of losing the pregnancy because of a partially detached placenta. Imai’s mother went to great lengths to ... Read More »

Depression, behavioral changes may precede memory loss in Alzheimer’s


Depression and behavioral changes may occur before memory declines in people who will go on to develop Alzheimer’s disease, according to new research at  Washington University School of Medicine  in St. Louis. Researchers have known that many people with Alzheimer’s experience depression, irritability, apathy and appetite ... Read More »

Not all obese people develop metabolic problems linked to excess weight​​​​


New research demonstrates that obesity does not always go hand in hand with metabolic changes in the body that can lead to diabetes, heart disease and stroke.  In a study at  Washington University School of Medicine  in St. Louis, researchers found that a subset of obese people do ... Read More »

Natural compound helps reverse diabetes in mice — Washington University Record


Researchers at Washington University School of Medicine in St. Louis have restored normal blood sugar metabolism in diabetic mice using a compound the body makes naturally... Read More »

Genetic variant linked to blocked heart arteries in patients with diabetes


Researchers at Washington University School of Medicine in St. Louis have identified the first genetic variant associated with severity of coronary artery disease in patients with type 2 diabetes. Read More »

Perhaps a longer lifespan, certainly a longer 'healthspan': Calorie restriction leads scientists to molecular pathways that slow aging, improve health


Organisms from yeast to rodents to humans all benefit from cutting calories. In less complex organisms, restricting calories can double or even triple lifespan. It’s not yet clear just how much longer calorie restriction might help humans live, but those who practice the strict diet hope to survive past 100 ... Read More »

Longer Life Foundation grants announced: Studies look to improve quality of life among elderly


The Longer Life Foundation has awarded grants to six research projects on issues related to aging at Washington University School of Medicine. Read More »

Longer Life Foundation awards five grants, seeks applications


The Longer Life Foundation, a cooperative effort between the School of Medicine and the Reinsurance Group of America (RGA), has awarded grants to five Washington University research projects looking at the genetics of aging, the effects of calorie restriction on aging and longevity, the relationship between cancer and aging, and ... Read More »